Central Venous Catheter Placement With Thoracic Ultrasound and Intracavity ECG Positioning (NCT07291869) | Clinical Trial Compass
RecruitingNot Applicable
Central Venous Catheter Placement With Thoracic Ultrasound and Intracavity ECG Positioning
United Kingdom75 participantsStarted 2026-05-15
Plain-language summary
The goal of this interventional study is to assess the feasibility of two bedside techniques for confirming central venous catheter (CVC) placement and detecting complications:
* Intracavity ECG monitoring to confirm internal jugular vein CVC tip position.
* Thoracic point-of-care ultrasound (POCUS) to rule out pneumothorax following CVC insertion.
Participants who require an internal jugular CVC as part of their routine care and meet all inclusion and no exclusion criteria will be randomised to receive either:
* Standard care, or
* The intervention, consisting of intracavity ECG guidance and thoracic POCUS. The CVC will be inserted either on the left or right side of the neck.
All participants will undergo a post-procedure chest X-ray regardless of study arm, to allow comparison of the intervention methods with standard care.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult (aged ≥ 18 years)
* Admitted, or planned for admission, to critical care
* Requiring central venous catheter insertion as a part of their usual care
* Suitable for both right or left internal jugular vein insertion
Exclusion Criteria:
* Previously randomised into CVC-TIP
* Atrial fibrillation on 12-lead ECG
* Cardiovascular instability, defined as
* Noradrenaline dose \> 0.5mcg/kg/min
* Rapidly escalating doses of vasopressors / inotropes
* Difficulty in obtaining thoracic ultrasound images due to either
* Weight \> 120kg
* Existing pneumothorax (either side)
* Subcutaneous emphysema
* Wounds / dressing over anterior chest wall
* Existing pacemaker
* Non-English speaking participants
* Death perceived as imminent
* Any other reason as determined by treating clinician
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Recruitment Rate
Timeframe: 12-month recruitment window
2
Protocol adherence
Timeframe: 12-month recruitment window
3
Data completeness
Timeframe: 12-month recruitment window
4
Training requirements
Timeframe: 12-month recruitment window
5
Technical success rate
Timeframe: 12-month recruitment window
6
Time taken for confirmation of central venous catheter tip positioning
Timeframe: 12-month recruitment window
Trial details
NCT IDNCT07291869
SponsorYork Teaching Hospitals NHS Foundation Trust