Comparative Evaluation of Clinical and Radiographic Treatment Outcomes of Garlic Gel and Calcium … (NCT07289971) | Clinical Trial Compass
Not Yet RecruitingPhase 3
Comparative Evaluation of Clinical and Radiographic Treatment Outcomes of Garlic Gel and Calcium Hydroxide as an Intracanal Medicament in Nonsurgical Root Canal Treatment of Permanent Teeth.
96 participantsStarted 2026-01-20
Plain-language summary
Researchers want to check how well garlic works inside permanent teeth as a medicament during root canal treatments. Garlic has shown to possess many helpful properties, like reducing inflammation, helping wounds heal, and antimicrobial characteristics. Because conventional medicaments can be expensive or have potential side effects, researchers are actively exploring natural options like garlic. Some lab studies have already shown that garlic gel can kill the microbes inside the teeth. However, no real-life clinical or X-ray studies have been done on using garlic in permanent teeth. This study may help scientists find a much safer and effective new material for dental treatments in the future.
Who can participate
Age range
15 Years – 45 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients with the physical status of ASA I and ASA II according to ASA classification.
* Patients aged from 15-45 years.
* Mature permanent single-rooted teeth with closed apices.
* Patients with clinical signs of symptomatic apical periodontitis (pain, tenderness to palpation, and percussion).
* Patients having radiographic evidence of periapical radiolucency of endodontic origin.
* Patients who have not taken antibiotics for the past 14 days.
* Cooperative patients who show good compliance.
Exclusion Criteria:
* Patients with physical status of ASA III, IV, and V according to ASA classification.
* Teeth with a calcified pulp chamber in periapical radiography.
* Patients who have undergone previous endodontic treatment failure and those with the presence of sinus tract on clinical examination.
* Teeth having advanced periodontal disease, with the basic periodontal examination (BPE) of 3 and 4.
* Presence of internal and external resorption of the root as viewed on the periapical radiograph.
* Presence of vertical root fracture and perforation as viewed on the periapical radiograph
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
CLINICAL AND RADIOGRAPHIC OUTCOMES
Timeframe: Time frame for clinical outcomes: Baseline to 2 weeks Time frame for radiographic outcomes: Baseline to 6 months