Clinical Study on the Therapeutic Efficacy of Biportal Endoscopic Decompression Spine Surgery and… (NCT07289737) | Clinical Trial Compass
RecruitingNot Applicable
Clinical Study on the Therapeutic Efficacy of Biportal Endoscopic Decompression Spine Surgery and Lumbar Decompression Fusion Surgery in the Treatment of Degenerative Lumbar Spondylolisthesis
China100 participantsStarted 2025-12-10
Plain-language summary
This study aims to systematically evaluate the therapeutic efficacy of dual-channel endoscopic spinal decompression versus lumbar decompression with fusion for degenerative lumbar spondylolisthesis. Patients undergoing either procedure will undergo detailed preoperative and postoperative follow-up to compare outcomes between the two techniques, specifically assessing postoperative pain relief, neurological improvement, and the incidence of surgical complications.
Who can participate
Age range50 Years – 90 Years
SexALL
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Inclusion criteria
✓. Aged between 50 and 90 years old with a confirmed diagnosis of degenerative lumbar spondylolisthesis;
✓. Clinical symptoms include chronic pain, nerve compression, or motor dysfunction, confirmed by imaging studies (e.g., MRI or CT);
✓. No significant improvement after at least 3 months of conservative treatment (e.g., medication, physical therapy), meeting surgical indications;
✓. Understand and consent to the relevant procedures of this study, and sign the informed consent form.
✕. Patients with a history of spinal surgery or conditions such as spinal deformities, severe osteoporosis, or active infections that may compromise surgical outcomes;
✕. Patients with severe comorbidities affecting assessment, such as cardiovascular disease, liver or kidney failure, or uncontrolled diabetes;
✕. Patients with psychiatric disorders or cognitive impairments preventing understanding or cooperation with the study process;
What they're measuring
1
VAS
Timeframe: 36 month
2
JOA score
Timeframe: 36month
3
ODI
Timeframe: 36month
Trial details
NCT IDNCT07289737
SponsorThe Fourth Affiliated Hospital of Zhejiang University School of Medicine