Phase 2b, Open Label, Multisite, Randomized Crossover Study of DPP Versus 2PR

Inclusion Criteria: * Age 16 through 39 years old (inclusive) at Screening. * Adults must be able and willing to provide informed consent. Adolescents (16- and 17-year-olds) will be consented according to applicable local guidelines, by obtaining participant assent and where applicable parental or guardian permission. * Able and willing to provide adequate locator information. * Able and willing to comply with all study procedures. * Must be post-menarche and pre-menopausal and could potentially become pregnant. * Sexually active, defined as having had penile-vaginal sex within the 3 months before Screening (per self-report) * Negative pregnancy test at Screening and Enrollment. * Does not intend to become pregnant within the next 12 months. * Willing to use COCs for at least 48 weeks as their method of contraception. * HIV negative at Screening and Enrollment. * Willing to use oral PrEP for at least 48 weeks. * Hepatitis B (HBV) surface antigen (HbsAg) negative per blood test at Screening. * Hepatitis C (HCV) negative at Screening. * Normal estimated creatinine clearance (eCrCl) ≥ 60 ml/min per blood test at Screening. Exclusion Criteria: * Intolerance, adverse reaction, or laboratory abnormality associated with PrEP use in the past. * Unable to become pregnant e.g., had a tubal ligation or hysterectomy or otherwise lacks a uterus, or is currently using another form of contraception. * Medically ineligible for combined hormonal contraception and specifically COCs per Worl…