The goal of this observational diagnostic study is to find how well two evaluation methods used during medical thoracoscopy can help identify whether pleural disease is malignant or benign. The study focuses on adults undergoing thoracoscopy for undiagnosed pleural effusion or suspected pleural disease. The main questions this study aims to answer are: How accurate is the thoracoscopist's visual assessment of the pleura in predicting malignancy? How accurate is Rapid On-Site Evaluation (ROSE) of touch-imprint cytology compared with final laboratory histopathology? Researchers will compare thoracoscopic visual impressions with ROSE results to determine which method provides more reliable real-time diagnostic information. Participants will: Undergo medical thoracoscopy as part of their clinical evaluation. Have pleural biopsy samples assessed on-site using ROSE. Have standard histopathology testing performed for final diagnosis. This study may help improve decision-making during thoracoscopy by identifying whether combining visual assessment with ROSE leads to faster and more accurate diagnosis of pleural disease.
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Diagnostic Accuracy of Rapid On-Site Evaluation (ROSE) and Visual assessment
Timeframe: Time Frame: During thoracoscopy (immediate assessment) with confirmation by final histopathology within 2-7 days