Comparing Polyglactin vs Polypropylene Sutures for Rectus Sheath Closure (NCT07280975) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Comparing Polyglactin vs Polypropylene Sutures for Rectus Sheath Closure
Pakistan156 participantsStarted 2026-04-01
Plain-language summary
This randomized controlled trial aims to compare the outcomes of Polyglactin (Vicryl) versus Polypropylene (Prolene) sutures for rectus sheath closure in patients undergoing midline laparotomy. The study will evaluate the rates of incisional hernia, surgical site infection (SSI), wound dehiscence, chronic pain, and suture sinus formation. Participants aged 18-70 years, undergoing either elective or emergency laparotomy, will be randomly assigned to receive either Polyglactin or Polypropylene sutures. The primary outcome measure is the incidence of incisional hernia at 6 months, with secondary outcomes including SSI, wound complications, and chronic pain. The study is particularly important in the context of Pakistan, where such comparative data is limited, and aims to provide evidence-based recommendations for optimal suture material selection in general surgery.
Who can participate
Age range
18 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Age: 18-70 years.
. Type of Surgery: Patients undergoing elective or emergency midline laparotomy.
. Wound Classification: Clean or clean-contaminated wounds (CDC Class I or II).
. Ability to Provide Informed Consent: Participants must be able to understand and sign the informed consent form.
. Availability for Follow-Up: Participants must be available for 6 months follow-up.
Exclusion criteria
. Contaminated or Dirty Wounds: Patients with CDC Class III or IV wounds.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Incisional Hernia rate
Timeframe: 6 months postoperatively
Trial details
NCT IDNCT07280975
SponsorLady Reading Hospital, Pakistan
Sponsor typeOTHER_GOV
Study typeINTERVENTIONAL
Primary completion2027-06-30
Contact for this trial
Dr. Atta Ullah Arif Associate Professor, MBBS, FCPS