Comparing Polyglactin vs Polypropylene Sutures for Rectus Sheath Closure (NCT07280975) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Comparing Polyglactin vs Polypropylene Sutures for Rectus Sheath Closure
Pakistan156 participantsStarted 2026-04-01
Plain-language summary
This randomized controlled trial aims to compare the outcomes of Polyglactin (Vicryl) versus Polypropylene (Prolene) sutures for rectus sheath closure in patients undergoing midline laparotomy. The study will evaluate the rates of incisional hernia, surgical site infection (SSI), wound dehiscence, chronic pain, and suture sinus formation. Participants aged 18-70 years, undergoing either elective or emergency laparotomy, will be randomly assigned to receive either Polyglactin or Polypropylene sutures. The primary outcome measure is the incidence of incisional hernia at 6 months, with secondary outcomes including SSI, wound complications, and chronic pain. The study is particularly important in the context of Pakistan, where such comparative data is limited, and aims to provide evidence-based recommendations for optimal suture material selection in general surgery.
Who can participate
Age range18 Years – 70 Years
SexALL
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Inclusion criteria
✓. Age: 18-70 years.
✓. Type of Surgery: Patients undergoing elective or emergency midline laparotomy.
✓. Wound Classification: Clean or clean-contaminated wounds (CDC Class I or II).
✓. Ability to Provide Informed Consent: Participants must be able to understand and sign the informed consent form.
✓. Availability for Follow-Up: Participants must be available for 6 months follow-up.
Exclusion criteria
✕. Contaminated or Dirty Wounds: Patients with CDC Class III or IV wounds.
✕. Immunocompromised Conditions: Patients on steroids, chemotherapy, or those with HIV.
✕. Previous Midline Laparotomy with Incisional Hernia: Patients who have a history of incisional hernia after midline laparotomy.
✕. Severe Malnutrition: Patients with BMI \< 16 kg/m² or albumin \< 2.5 g/dL.
What they're measuring
1
Incisional Hernia rate
Timeframe: 6 months postoperatively
Trial details
NCT IDNCT07280975
SponsorLady Reading Hospital, Pakistan
Sponsor typeOTHER_GOV
Study typeINTERVENTIONAL
Primary completion2027-06-30
Contact for this trial
Dr. Atta Ullah Arif Associate Professor, MBBS, FCPS