RecruitingPhase 2

Cannabidiol and Alcohol Use Disorder Phenotypes

United States150 participantsStarted 2026-03-31

Plain-language summary

The goal of this study is to learn how CBD affects drinking in people who drink alcohol regularly. Researchers want to see if CBD can help people drink less and reduce problems related to alcohol use.

Who can participate

Age range21 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Age 21-65
✓. Have used CBD and cannabis at least once in the last year
✓. Regularly drink alcohol
✓. Able to provide informed consent and attend in-person study visits

Exclusion criteria

✕. Current use of medications known to have major interaction with Epidiolex, Marinol, or alcohol
✕. Current use of antiepileptic medication or any psychotropic medication besides antidepressants
✕. Pregnant, nursing, or planning a pregnancy
✕. Medical conditions that contraindicates the use of CBD or alcohol
✕. Current medical conditions that may require intensive care during the study period

What they're measuring

Alcohol Self-Administration During the Bar Lab Task

Timeframe: Week 8

Change in Self-Report of Drinking Behavior (Drinks Per Drinking Day)

Timeframe: Baseline, Week 4, Week 8, and Week 12

Change in Phosphatidylethanol (PEth)

Timeframe: Baseline, Week 4, Week 8, and Week 12

Trial details

NCT IDNCT07279558

SponsorUniversity of Colorado, Denver

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2029-08-31

Contact for this trial

Hollis C Karoly, PhD

303-724-7179 hollis.karoly@cuanschutz.edu

View on ClinicalTrials.gov More Alcohol Use Disorder trials