The purpose of this study is to evaluate the safety, tolerability, dosimetry and preliminary efficacy of \[212Pb\]Pb-MP0712, in patients aged ≥18 years with Small Cell Lung Cancer and other locally advanced or metastatic DLL3 positive tumors.
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To assess incidence and severity of safety events following administration of [212Pb]Pb-DOTAM-MAM279
Timeframe: until 5 years after last dose
To assess dose modifications of [212Pb]Pb-DOTAM-MAM279
Timeframe: until 5 years after last dose
To estimate the maximum tolerated dose (MTD) and/or to define the recommended phase 2 dose (RP2D) for SCLC/LCNEC of the lung and epNECs
Timeframe: Phase 1, from start of treatment to end of first cycle (day 1 - 28)
To evaluate the preliminary anti-tumor activity of [212Pb]Pb-DOTAM-MAM279 in the dose expansion part
Timeframe: Phase 2a only; 12 months