Testosterone Replacement Therapy in Hypogonadal Patients With Prostate Cancer Under Active Surveillance

Inclusion Criteria: * Males aged ≥ 18 years old * Newly diagnosed with low-risk prostate cancer initially confirmed by fusion guided prostate biopsy (transrectal or trans perineal) by multiparametric MRI, and had a second confirmatory biopsy within the last 12 months * Males diagnosed with low-risk prostate cancer undergoing active surveillance * Two confirmatory testosterone levels \<300 ng/dL (taken before 10am), with at least 24 hours and no more than 90 days between the two tests * Symptoms of low testosterone (Aging Male's Symptoms Score \>27) * Able to obtain Testosterone medication through insurance or out-of-pocket * Willing and able to provide written informed consent and able to comply with study requirements Exclusion Criteria: * Males \<18 years old * History of Testosterone Replacement Therapy (TRT) within the past year. * Current use of TRT * Diagnosis of Gleason score 7 (Grade Group 2) prostate cancer or higher on diagnostic or confirmatory biopsy * PSA \>10 ng/mL at baseline * Hematocrit \> 51% at baseline * T3 or T4 disease * Uncontrolled cardiovascular disease and sleep apnea * History of breast cancer * Any other condition or situation which, in the opinion of the investigator, could impact patient safety, prevent successful data collection, or reduce the likelihood of successful study participation * Unable or unwilling to obtain Testosterone medication through insurance or out-of-pocket * Unable or unwilling to provide informed consent or comply with s…