Long-Term Study of CartiPRO for Knee Pain Due to Osteoarthritis or Cartilage Damage

Inclusion Criteria * Age 19 years and older * Diagnosed with unilateral or bilateral knee osteoarthritis according to American College of Rheumatology (ACR) criteria, with at least 3 of the following 6 features: * Age ≥50 years * Morning stiffness \<30 minutes * Crepitus on active motion * Bony tenderness * Bony enlargement * No palpable warmth * Radiographic evidence of Kellgren-Lawrence grade I, II, or III osteoarthritis within 6 months prior to screening or at screening visit * Weight-bearing pain Visual Analogue Scale (VAS) score ≥40 mm in at least one knee joint at screening * Able to walk without assistive devices (walkers or canes), OR if using a walking aid routinely for past 6 months, able to continue using the same device throughout the study * Able to understand and complete efficacy assessment questionnaires * Willing and able to provide written informed consent Exclusion Criteria * Body Mass Index (BMI) ≥32 kg/m² * Chronic inflammatory joint disease (e.g., rheumatoid arthritis) * Inflammatory joint disease (e.g., septic arthritis) * Secondary knee osteoarthritis due to ochronosis, hemochromatosis, or systemic disease * Painful musculoskeletal conditions (e.g., Sudeck's atrophy, Paget's disease, herniated intervertebral disc) * Polyarticular disease with severe osteoarthritis in other joints (e.g., hip) that may affect knee pain evaluation * Radiographic evidence of definite loss of patellofemoral joint space * Moderate to severe joint effusion con…