Switching From Xiidra to TRYPTYR

Inclusion Criteria: * Adults ≥18 years of age. * Have a history of DED for at least the past 6 months. * Are currently using Xiidra as directed by their eye care provider for ≥1 month. * Are symptomatic as determined with SPEED (≥7) and have an abnormal Schirmer test score \[≥2 to \<10 mm/5 min\]) at Screening/Baseline. If Shirmer only qualifies for one eye, that will be the study eye. If Shirmer qualifies for both eyes, the right eye will be the study eye. * Have corrected distance visual acuity of 20/40 or better. * Willing to discontinue contact lens wear 24 hours prior to screening visit and throughout the study. Exclusion Criteria: * Have a systemic health condition that is known to alter tear film physiology (e.g., primary and secondary Sjögren's syndrome). * Have a history of ocular surgery within the past 12 months. * Have a history of severe ocular trauma, active ocular infection or inflammation that is not dry eye related. * Punctal plugs in place for \< 3 months and/or Lacrifill in place for \> 5 months. * Have ever used Accutane * Currently using ocular medications, including topical anti-inflammatory drops, (other than Xiidra) 1 month prior to enrollment * Any artificial tear use at enrollment must remain consistent throughout the study. * Are pregnant or breast feeding. * Have had a physical meibomian gland treatment withing 1 month of enrollment. * Initiated, discontinued or changed dose of a systemic medication known to cause ocular drying (e.g., antihistam…