Study of JTM104 Injection vs. Juvederm in Treating Moderate to Severe Nasolabial Folds

Inclusion Criteria: * Adults aged 19 to 75 years * Voluntarily provided written informed consent * Moderate to severe symmetrical nasolabial folds (WSRS score 3 or 4 on both sides) * Agree to discontinue other facial dermatologic treatments (e.g., fillers, botulinum toxin, laser) during the study * Able to understand instructions and comply with study procedures Exclusion Criteria: * Untreated scars or facial skin infections/diseases affecting the mid/lower face within the past year * History of severe allergy or hypersensitivity to device components * Facial invasive procedures within the past 6 months (including surgery, laser, botulinum toxin) * Use of certain medications (anticoagulants, immunosuppressants, steroids) within specified washout periods * Participation in other interventional clinical trials within 4 weeks before screening or during study * Non-compliance with contraception requirements or pregnancy/lactation during study * Deemed unsuitable by investigator for any other reason