to Evaluate the Safety and the Pharmacokinetic and Pharmacodynamic Interactions between JP-1366 and Clopidogrel, Aspirin, Atorvastatin and Apixaban
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[Part 1] Change in P2Y12 Reaction Unit (PRU) from baseline on day 8
Timeframe: baseline on day 8
[Part 2] Emax of arachidonic acid-induced platelet aggregation
Timeframe: up to 48 hours post-dose on Day 1
[Part 2] AUEC0-24 of arachidonic acid-induced platelet aggregation
Timeframe: up to 48 hours post-dose on Day 1
[Part 2] Cmax,ss of JP-1366
Timeframe: up to 24 hours post-dose on Day 5
[Part 2] AUCÏ„,ss of JP-1366
Timeframe: up to 24 hours post-dose on Day 5
[Part 2] Cmax of Aspirin
Timeframe: up to 48 hours post-dose on Day 1
[Part 2] AUClast of Aspirin
Timeframe: up to 48 hours post-dose on Day 1
[Part 3] Cmax,ss of JP-1366
Timeframe: up to 24 hours post-dose on Day 5
[Part 3] AUCÏ„,ss of JP-1366
Timeframe: up to 24 hours post-dose on Day 5
[Part 3] Cmax,ss of Atorvastatin
Timeframe: up to 24 hours post-dose on Day 5
[Part 3] AUCÏ„,ss of Atorvastatin
Timeframe: up to 24 hours post-dose on Day 5
[Part 4] Emax of Anti-Factor Xa activity
Timeframe: up to 48 hours post-dose on Day 5
[Part 4] AUEC0-12 of Anti-Factor Xa activity
Timeframe: up to 48 hours post-dose on Day 5
[Part 4] Cmax,ss of JP-1366
Timeframe: up to 24 hours post-dose on Day 5
[Part 4] AUCÏ„,ss of JP-1366
Timeframe: up to 24 hours post-dose on Day 5
[Part 4] Cmax,ss of Apixaban
Timeframe: up to 12 hours post-dose on Day 5
[Part 4] AUCÏ„,ss of Apixaban
Timeframe: up to 12 hours post-dose on Day 5