Investigating the Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on the Brain in … (NCT07260864) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Investigating the Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on the Brain in People With Fibromyalgia
United States20 participantsStarted 2025-12-30
Plain-language summary
The first goal of this study is to see how brain activity changes in people with fibromyalgia after they get a treatment called rTMS (repetitive transcranial magnetic stimulation). Researchers are looking at how the parts of the brain that control movement (called motor cortices) respond to this treatment.
The second goal is to find out if the changes in brain activity are different between the right and left sides of the brain, depending on which side gets the treatment.
Who can participate
Age range18 Years – 65 Years
SexFEMALE
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Inclusion Criteria:
* Female aged 18 to 65, right-handed, with no racial/ethnic restrictions.
* A diagnosis of fibromyalgia by a qualified physician according to the American College of Rheumatology 2016 criteria
* Must have a history of fibromyalgia pain for a duration ≥ 3 months, as it is included in the diagnostic criteria.
* Must have pain intensity equal or greater than 4/10 on the numerical rating scale (NRS) at enrollment.
* Concurrent chronic overlapping pain conditions (except migraine with aura), depression, and anxiety will be allowed when mild to moderate (Less than 31 on Beck Depression Inventory or less than 36 on Beck Anxiety Inventory), except in cases with psychotic or manic features.
* Concomitant medication (except tricyclics, antipsychotic medications, bupropion, methadone, theophylline) and their doses for mood, pain and sleep disorders must be steady at least 4 weeks before enrolment and must be kept at a steady dosage during the trial.
* Must be able to read and speak English and be willing to read and understand instructions as well as questionnaires.
* Must be in generally stable health.
* Must sign an informed consent document after explanation of the study documenting that they understand the purpose of the study, procedures to be undertaken, possible benefits, potential risks, and are willing to participate.
Exclusion Criteria:
* Inability to provide informed consent.
* Age outside the studied range (i.e., \< 18, \> 65).
* Patients planning to c…
What they're measuring
1
Mean Change in Primary Motor Cortex (M1) Connectopy Profile
Timeframe: Baseline and post-treatment (after 10 sessions of rTMS over 2 weeks).