Not Yet RecruitingPhase 2

Safety and Efficacy of Lidocaine Versus Ketamine Infusion for Resistant Orofacial Pain

105 participantsStarted 2026-01

Plain-language summary

A prospective, randomized, double-blind clinical trial comparing the safety and efficacy of intravenous lidocaine, ketamine, and their combination as treatment options for patients suffering from treatment-resistant orofacial pain. The study measures pain reduction primarily using the Visual Analog Scale and evaluates safety and tolerability over a follow-up period of 6 months.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: \- Adults aged \> 18 years Resistant orofacial pain patients with failed medical or interventional treatment Diagnosed with one or more of the following: Trigeminal neuralgia Temporomandibular joint (TMJ) dysfunction Malignant otitis externa Migraine Atypical facial pain Exclusion Criteria: \- Debilitating cardiac disease Uncontrolled hypertension Known allergies to lidocaine or ketamine Severe renal or hepatic impairment Pregnancy or breastfeeding History of substance abuse

What they're measuring

Change in Visual Analog Scale (VAS) Pain Score

Timeframe: Baseline, prior to 2nd infusion, prior to 3rd infusion, 1 month, 3 months, and 6 months after intervention

Trial details

NCT IDNCT07250867

SponsorAssiut University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-01

View on ClinicalTrials.gov More Orofacial Pain trials