Strategies for Proactive Health in People With Kidney Function Decline (NCT07245186) | Clinical Trial Compass
By InvitationNot Applicable
Strategies for Proactive Health in People With Kidney Function Decline
China1,800 participantsStarted 2021-01-01
Plain-language summary
This prospective cohort study aims to investigate how kidney function decline affects multiple body systems and how personalized nutrition can help maintain health and slow disease progression. About 1,800 adults with reduced kidney function but not on dialysis will be followed over time at Huashan Hospital, Fudan University. The study will collect information on nutrition, heart and bone health, cognition, and daily functioning through hospital records and a patient mobile app. The goal is to understand the links between nutrition, metabolism, and organ function, and to develop integrated strategies for early prevention and management of chronic kidney disease.
Who can participate
Age range18 Years – 90 Years
SexALL
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Inclusion criteria
✓. Non-dialysis patients with chronic kidney disease (CKD) stages 1-5.
✓. Aged 18 to 90 years, no restriction on gender.
✓. Sufficient health literacy or a family member with adequate literacy to comply with dietary diary recording and other study procedures.
✓. Stable primary disease of CKD at the time of enrollment.
Exclusion criteria
✕. Patients with malignancies, severe cardiovascular diseases, osteoporosis, or severe hematological disorders.
✕. Active infections (CRP \>10 mg/L) or current use of nephrotoxic drugs.
✕. Limb paralysis or amputation.
✕. Use of immunosuppressants (cyclosporine, tacrolimus) within the past 3 months or steroid therapy equivalent to prednisone \>10 mg/day.
✕. Severe gastrointestinal diseases affecting nutrient absorption.
What they're measuring
1
Rapid decline in renal function
Timeframe: eGFR will be measured at baseline and at 1 month, 3 months, 6 months, 9 months, 12 months, 18 months, 24 months, 30 months, and 36 months after enrollment, and subsequently every 6 months thereafter up to 10 years of follow-up.