Neuromuscular Rehab for ACL Reconstruction: Knee Function & Brain Plasticity (NCT07243860) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Neuromuscular Rehab for ACL Reconstruction: Knee Function & Brain Plasticity
China50 participantsStarted 2025-12-01
Plain-language summary
This study focuses on patients with anterior cruciate ligament (ACL) rupture and reconstruction, aiming to systematically investigate the clinical efficacy and underlying mechanisms of neuromuscular training in restoring knee joint function.Beyond examining improvements in local knee biomechanics, the research delves into brain plasticity changes during rehabilitation to reveal the central regulatory mechanisms of neuromuscular control.The findings are expected to provide a solid theoretical and empirical foundation for optimizing post-ACL rehabilitation strategies, fostering interdisciplinary integration from peripheral interventions to neural central regulation.
Who can participate
Age range18 Years – 45 Years
SexALL
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Inclusion criteria
✓. Body Mass Index (BMI) ≥18.5 kg/m² and \<35 kg/m²;
✓. No or only mild concomitant injuries to the posterior cruciate ligament, medial collateral ligament, or lateral collateral ligament;
✓. Voluntarily participated in the study and provided written informed consent .
Exclusion criteria
✕. Patients with ACL rupture for more than 6 months;
✕. Combined severe injuries (Grade II or higher) to the posterior cruciate ligament, medial collateral ligament, or lateral collateral ligament(Grading Note: Grade II indicates partial tear with ligament thickening, tortuosity, and fiber disruption; Grade III indicates complete rupture);OR combined severe meniscal tears ;
✕. History of prior knee surgery (e.g., meniscal repair, ligament reconstruction, arthroplasty, arthroscopic debridement);
✕. Presence of other knee pathologies: knee osteoarthritis, tumors, rheumatoid arthritis, tuberculosis, infectious or inflammatory diseases, fractures, dislocations, or other skeletal injuries;
What they're measuring
1
isokinetic muscle strength
Timeframe: Pre-intervention and preoperative intervention, at 12 weeks and 12 months postoperatively
2
sEMG
Timeframe: Pre-intervention and preoperative intervention, at 12 weeks and 12 months postoperatively
3
Three-Dimensional Gait Analysis using the Vicon System
Timeframe: Pre-intervention and preoperative intervention, at 12 weeks and 12 months postoperatively
4
Electroencephalography Assessment
Timeframe: Pre-intervention and preoperative intervention, at 12 weeks and 12 months postoperatively