SYSTANE® PRO vs. MIEBO™ in Dry Eye Disease (NCT07243275) | Clinical Trial Compass
CompletedPhase 4
SYSTANE® PRO vs. MIEBO™ in Dry Eye Disease
United States269 participantsStarted 2026-02-18
Plain-language summary
This is a prospective, randomized, double-masked, multi-site clinical trial designed to compare the efficacy of SYSTANE® PRO (Alcon Laboratories, Inc.) to MIEBO™ (Bausch + Lomb) in treating symptoms of evaporative dry eye disease (DED). The primary goal is to determine whether SYSTANE® PRO is non-inferior to MIEBO™ after one month of treatment, based on change in Ocular Surface Disease Index (OSDI) scores.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults\>=18 years of age
* Corrected visual acuity of 20/100 or better in both eyes
* Ocular Surface Disease Index \[OSDI\] scores between 23 and 50 units \[inclusive\]
* Tear break up time score of \<=5 seconds in both eyes
* Schirmer I test (without anesthesia) \>=5 mm in both eyes
Exclusion Criteria:
* Discontinue contact lens wear starting 7 days prior and throughout the study
* Artificial tears and warm compresses should not be used for at least one week prior to enrollment and throughout the study
* Systemic health conditions that are known to alter tear film physiology(e.g., primary and secondary Sjogren's syndrome)
* History of ocular surgery within the past 12 months
* History of severe ocular trauma, active ocular infection or inflammation, have ever used Accutane or are currently using ocular medications.
* Women who are pregnant or breast feeding(self report)
* Subjects with a condition or in a situation, which in the investigator's opinion, may put the subject at significant rist, may confound the study results, or may significantly interfere with their participation in the study
* Subjects will not be allowed to use any other topical eye drops or other dry eye treatments beyond their assignment during the study
* Participants in clinical trial or study using a device, topical, or oral therapeutic in the past 3 months of enrollment
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.