Comparison of Demineralized and Mineralized Dentin Grafts in Ridge Preservation (NCT07242313) | Clinical Trial Compass
RecruitingNot Applicable
Comparison of Demineralized and Mineralized Dentin Grafts in Ridge Preservation
Egypt45 participantsStarted 2025-10-21
Plain-language summary
This clinical investigation aims to assess how two different allogeneic dentin graft materials - one de-mineralized and the other mineralized - influence bone preservation following extraction of a single upper posterior tooth. A total of 45 patients will be randomly allocated into three equal groups: a socket-only spontaneous healing group (control), a de-mineralized dentin graft group, and a mineralized dentin graft group. Over a six-month period after extraction, measurements will be taken using CBCT to monitor changes in ridge width, height, and bone density. Secondary outcomes include patient-reported pain, postoperative swelling, satisfaction levels, width of keratinized tissue, and histomorphometric data from biopsy samples at implant placement. Findings from this trial may support evidence-based decisions in alveolar ridge preservation and help clinicians choose the most predictable grafting strategy before implant placement.
Who can participate
Age range
18 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
Adults aged 18 to 60 years.
Medically healthy patients classified as ASA I.
Presence of a single non-restorable tooth indicated for extraction in the posterior maxilla.
Adequate oral hygiene, with plaque and bleeding indices both below 20%.
Sufficient bone volume to allow socket preservation without requiring simultaneous augmentation.
Patients willing to participate in the study and able to provide written informed consent.
Ability to commit to follow-up visits for up to 6 months.
Exclusion Criteria:
Smokers or tobacco users of any form.
Presence of uncontrolled systemic diseases (e.g., uncontrolled diabetes).
Conditions affecting bone metabolism (e.g., osteoporosis, long-term corticosteroid therapy).
Pregnant or lactating women.
History of radiotherapy in the head and neck region.
Active infection or suppuration at the extraction site.
Immunocompromised patients or those on immunosuppressive therapy.
Patients taking medications known to impair healing (e.g., bisphosphonates).
Allergy or hypersensitivity to any study-related materials.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Alveolar Ridge Width (Buccolingual Dimension)
Timeframe: Baseline (immediately after extraction) and 6 months post-operative
2
Change in Alveolar Ridge Height (Vertical Dimension)