By InvitationNot Applicable

Early Recurrence After Surgery for Pancreatic Cancer

Italy500 participantsStarted 2025-10-23

Plain-language summary

The goal of this observational study is to learn about early recurrence after curative-intent surgery for pancreatic cancer. The main questions it aims to answer are: * How often does early recurrence (within 12 months after surgery) occur? * When does it happen, and at which anatomical sites (liver, lung, local, peritoneum)? * How is recurrence detected (imaging or tumor markers)? Adults with histologically confirmed pancreatic ductal adenocarcinoma who undergo curative-intent resection without distant metastases will be enrolled. Participants will be followed according to routine clinical care at each hospital, typically with imaging and CA19-9 blood tests. No study-specific interventions are required.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * Age ≥18 years * Histologically confirmed pancreatic ductal adenocarcinoma (PDAC) * Undergoing curative-intent resection (R0 or R1) * No evidence of distant metastasis at the time of surgery * Availability of preoperative CA19-9 value and pancreas-protocol CT or MRI * Ability to provide written informed consent Exclusion Criteria: * Withdrawal of informed consent * Pathological diagnosis other than PDAC (e.g., neuroendocrine tumor, acinar cell carcinoma, invasive IPMN) * Surgery performed for palliative or diagnostic purposes only * Intraoperative discovery of unresectable disease or distant metastases * Gross residual disease (R2 resection) * Incomplete clinical or radiologic follow-up precluding recurrence assessment * Absence of adequate preoperative contrast-enhanced pancreas-protocol CT or MRI preventing accurate staging and metastatic evaluation * Interval \>9 months between two consecutive follow-up visits * Major protocol deviations or insufficient data, as judged by the site investigator

What they're measuring

Incidence, timing, mode of detection, and anatomical site of early recurrence

Timeframe: Within 12 months post-surgery

Trial details

NCT IDNCT07241676

SponsorAzienda Ospedaliera di Padova

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-09-30