A Clinical Study on the Treatment of Wilson Disease With ATP7B mRNA/LNP (DSL101) (NCT07240896) | Clinical Trial Compass
RecruitingEarly Phase 1
A Clinical Study on the Treatment of Wilson Disease With ATP7B mRNA/LNP (DSL101)
China18 participantsStarted 2025-12-31
Plain-language summary
This study adopted an open, single-arm, non-randomized, dose-escalation research design, aiming to evaluate the safety, tolerability, preliminary efficacy, pharmacokinetic and immunogenicity characteristics of single and multiple intravenous infusions of DSL101 in patients with Wilson's disease.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Age ≥18 years old, gender not limited.
✓. Meet the diagnostic criteria f Wilson's Disease in "Guidelines for Diagnosis and Treatment of Wilson's Disease (2022 Edition)", with a Leipzig score ≥4, at least one year between diagnosis and screening; ceruloplasmin level \<0.1g/L.
✓. Patinets with Wilson's disease confirmed by laboratory tests to have double-chromosome mutations in the ATP7B gene.
✓. Low copper diet for at least six months befoer screening and willing to continue low copper diet during study.
✓. Fertile subjects agreed to adopt reliable contrraceptive methods from the screening until 6 months after the last administration.
✓. The subjects are atable patients with WD who have been trasted for at least six months without drug or dose changes for at least 6 momths at the time of screening , and have continuously used standard treatments \[SOC, such as D-penicillamine, sodiu dihydroxypropane sulfonate, dimercaptosuccinic acid, trientine, and zinc preparations (zinc acetate, zinc gluconate, zinc sulfate)\] for at least 6 months screening, and allowed subjects to continue with their prior SOC treatment.
✓. The subject's condition was fully controlled after treatment, and its definition must meet all of the following conditions:
✕. Other liver-related diseases and clinical symptoms that can cause liver injury, such as acute and chronic hepatitis, alcoholic liver disease, autoimmune liver disease, drug-induced liver injury, liver cirrhosis, liver ascites, esophageal varices, hepatic encephalopathy, hepatorenal syndrome, liver failure, liver malignancy, etc.; Subjects with Model for end-stage liver disease score (MELD)\>13.
✕. Other diseases that can cause hemolysis or anemia, such as erythrocytosis, Mediterranean anemia, hemolytic anemia, various causes of infection, large area burns, etc.
✕. Other diseases that can cause dysfunction of the nervous system, such as Parkinson's disease, Parkinson syndrome, various causes of dystonia, chorea, primary tremor, epilepsy, mental abnormalities (such as history of schizophrenia or suicide attempts), etc.
✕. Screening period laboratory examination indicators: