A Study of BGM0504 Tablets in Healthy and Non-diabetic Overweight or Obese Chinese Subjects

Exclusion criteria

• ✕. fasting serum glucose≥ 7.0mmol/L, or post-prandial glucose (PPG)-2h≥ 11.1mmol/L in oral glucose tolerance test (OGTT); (During screening, participants with fasting serum glucose ranging from 6.1 to 6.9mmol/L shall undergo the OGTT.)
• ✕. ALT, AST ≥ 2.5 times upper limit of normal (ULN) or total bilirubin ≥ 1.5 times upper limit of normal (ULN)
• ✕. Glomerular filtration rate (eGFR) ≤ 80 mL/min/1.73 m2(using CKD-EPI formula) or positive urine protein 2+ or more.
• ✕. Serum calcitonin level ≥ 35 ng/L (pg/mL);
• ✕. Thyroid-stimulating hormone (TSH) \> 6.0mIU/L or \< 0.4mIU/L;
• ✕. Fasting triglycerides ≥ 5.64mmol/L (500 mg/dL);
• ✕. Hemoglobin (Hgb) \< 100 g/L (for females) or \< 110 g/L (for males);