Influence of Maintaining Apical Patency on Post-Endodontic Pain in Molars (NCT07239752) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Influence of Maintaining Apical Patency on Post-Endodontic Pain in Molars
48 participantsStarted 2026-02-10
Plain-language summary
This randomized controlled trial will investigate if maintaining apical patency-a technique where a small file is gently moved past the root's end during cleaning-affects pain after a root canal. The study will include 48 adult patients needing root canal treatment on a back molar tooth with a dead nerve and infection at the root tip. Participants will be randomly assigned to one of two groups: one where the apical patency technique is used, and one where it is not. All other treatment steps will be identical. Patients will record their pain levels on a standard scale (0-100 mm Visual Analog Scale) at 6, 12, 24, 48, and 72 hours after the procedure. The goal is to determine if this specific technique influences the intensity and duration of post-treatment pain
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:Adult patients aged 18-65 years.
Medically healthy, classified as American Society of Anesthesiologists (ASA) Physical Status I or II.
Presence of a single permanent molar tooth diagnosed with necrotic pulp and symptomatic apical periodontitis, and indicated for primary root canal treatment.
Patients who provide informed written consent to participate in the study. -
Exclusion Criteria:
Teeth with prior endodontic treatment or complex anatomy (e.g., calcified canals, severe curvature).
Patients with significant systemic illness (e.g., uncontrolled diabetes, immunocompromised status) or pregnancy.
History of analgesic intake within 72 hours prior to the root canal procedure.
Non-restorable teeth, teeth with severe periodontal disease (pocket depth \>5mm), or teeth with root fractures.
Exclusion Criteria:
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Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Post-operative Pain Intensity
Timeframe: 6 hours after the completion of the root canal procedure
2
Post-operative Pain Intensity at 6 hours
Timeframe: 6 hours after the completion of the root canal procedure.
3
Post-operative Pain Intensity at 12 hours
Timeframe: 12 hours
4
Post-operative Pain Intensity at 48 hours
Timeframe: 48 hours
5
Post-operative Pain Intensity
Timeframe: 12 hours after the completion of the root canal procedure
6
Post-operative Pain Intensity
Timeframe: 24 hours
Trial details
NCT IDNCT07239752
SponsorCollege of Physicians and Surgeons Pakistan