Effect of Remote Ischemic Preconditioning on Early Neurological Deterioration in Acute Perforatin… (NCT07237542) | Clinical Trial Compass
RecruitingNot Applicable
Effect of Remote Ischemic Preconditioning on Early Neurological Deterioration in Acute Perforating Artery Infarction
China910 participantsStarted 2025-12-11
Plain-language summary
This study aims to conduct a prospective, randomized, double-blind, multicenter, parallel-controlled, group-sequential trialto scientifically evaluate the safety and efficacy of remote ischemic preconditioning (RIC) in preventing early neurological deterioration (END) in patients with acute perforating artery infarction (PAI).
Who can participate
Age range18 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Age 18 years or older;
✓. Diagnosed with acute ischemic stroke;
✓. Clinical symptoms consistent with perforating artery infarction (NIHSS score ≤5, with consciousness item 1a ≤1);
✓. Time from onset to randomization within 48 hours;
✓. Diffusion-weighted imaging (DWI) showing a single infarct in the perforating artery territory with a maximum diameter ≤30 mm, meeting at least one of the following:
Exclusion criteria
✕. Received intravenous thrombolysis or endovascular treatment prior to randomization;
✕. Secondary stroke caused by brain tumor, traumatic brain injury, hematologic disorders, or other conditions;
✕. History of intracranial hemorrhage;
✕. Presence of RIC contraindications, such as severe upper limb soft tissue injury, fracture, subclavian artery stenosis, or peripheral vascular disease;
✕. Uncontrolled severe hypertension (systolic blood pressure \[BP\] ≥180 mmHg or diastolic BP ≥110 mmHg);
✕. Severe hepatic or renal dysfunction (Alanine Aminotransferase or Aspartate Aminotransferase \> 3 × upper limit of normal; creatine kinase \>3 × upper limit of normal; estimated Glomerular Filtration Rate \< 30 mL / min / 1.73 m²);