CompletedNot Applicable

Muscle Recovery After Omega-3 Supplementation

Chile30 participantsStarted 2021-09-01

Plain-language summary

In recent decades, omega-3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been proposed as potential therapeutic agents for minimizing muscle damage induced by eccentric exercise, especially when supplementation is long-term (\> 6 weeks) and at high doses (\> 1 g/d). However, no study has analyzed whether these effects are mediated by an increase in oxylipins (metabolites derived from EPA and DHA), which play an essential role in the muscle regeneration process. The objective of the present study is to determine the effect of eight weeks of high-dose omega-3 fatty acid supplementation on blood oxylipin levels and their association with muscle function and markers of muscle damage after high-intensity eccentric exercise in young men.

Who can participate

Age range18 Years – 40 Years

SexMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy male participants between 18 and 40 years Exclusion Criteria: * Participants must not have performed regular strength training during the 6 months prior to the start of the study. * Participants must also not be taking medications that affect inflammation or cardiovascular responses to exercise and must have a BMI of less than 30 kg/m2. * Participants must not consume fish more than twice a week and must not have taken any omega-3 supplements for three months prior to the study or be allergic to fish.

What they're measuring

Maximum isometric voluntary contraction strength loss

Timeframe: Pre and post intervention (8 weeks)

Plasma oxylipins

Timeframe: Pre and post intervention (8 weeks)

Trial details

NCT IDNCT07237113

SponsorInstituto de Ciencias de la Salud, Universidad de O'Higgins

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-09-01