Labile Iron Removal by Adding the Iron Chelator MEX-CD1 to Dialysate in Sepsis-Associated Acute Kidney Injury

Inclusion Criteria: * Adult patients (≥18 years) admitted to ICU with sepsis-associated AKI requiring CRRT * Sepsis defined according to SEPSIS-3 criteria (suspected/documented infection with organ dysfunction indicated by ≥2-point increase in SOFA \[Sequential Organ Failure Assessment\] score) * AKI Stage 3 per KDIGO (Kidney Disease: Improving Global Outcomes) criteria: acute rise in serum creatinine ≥3 times baseline or serum creatinine ≥4 mg/dL or urine output \<0.3 mL/kg/h for ≥24 hours or anuria (urine output \<100ml) for ≥12 hours * Indications for CRRT: refractory hyperkalemia (\>6 mmol/L) or refractory metabolic acidosis (pH \< 7.20) or acute pulmonary edema unresponsive to medical management or urine output \<0.3 ml/kg/hour or anuria (urine output \<100ml) persistent for 48 hours and refractory to medical treatment * Informed consent obtained from patient or legal representative * Affiliated with or beneficiary of a health insurance plan Exclusion Criteria: * Known shellfish allergy * Moribund status with life expectancy too low to benefit * Concurrent participation in another interventional study * Exclusion period defined by another study * Under legal protection (guardianship or curatorship) * Inability to obtain informed consent from patient or representative * Pregnant, parturient, or breastfeeding women