Effects of tES Combined With CMDT Gait Training on Cognition, Cortical Activity, Spinal Motoneuro… (NCT07236216) | Clinical Trial Compass
RecruitingNot Applicable
Effects of tES Combined With CMDT Gait Training on Cognition, Cortical Activity, Spinal Motoneuron Excitability and Motor Performance in Stroke Individuals
Thailand60 participantsStarted 2025-12-20
Plain-language summary
The present study will use transcranial electrical stimulation (tES) which are transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) combined with conventional physical therapy and cognitive-motor dual task gait training in sub-acute (at least 2 weeks after stroke onset) to chronic (within 5 years post-stroke) to investigate the effect on cortical activity, spinal motoneuron excitability, cognition and motor performance. The findings may enhance the evidence to support usages of tES for improvimg cognition, motor performance as well as cortical activity and spinal motoneuron excitability in a clinical setting.
Who can participate
Age range18 Years – 80 Years
SexALL
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Inclusion criteria
✓. Unilateral stroke individuals aged 18-80 years.
✓. A first-ever stroke.
✓. Stroke onset from at least 2 weeks-5 years.
✓. Able to walk independently with or without gait aids (modified Rankin scale (mRS) 1-3)
✓. Montreal cognitive Assessment-Thai version (MoCA-T) greater than or equal to 20 scores.
✓. Ability to read, communicate, follow and understand instructions.
Exclusion criteria
✕. Presence of any psychological or neurological antecedent, unstable medical conditions or condition that may increase risk of stimulation such as epilepsy, seizure, and history of brain injury
✕. Having unstable cardiovascular disease or respiratory disease, and uncontrolled chronic disease such as diabetes mellitus (DM), hypertension (HT) and chronic kidney disease (CKD)
✕. Receiving other non-invasive brain stimulation or additional intervention such as TMS, PMS or acupuncture
What they're measuring
1
Fugl-Meyer assessment (FMA) of upper and lower extremities
Timeframe: Baseline, 1-day post-intervention, 1-month follow-up, and 3-month follow-up