The study "Cryopreservation of Platelets for Prophylactic Use in Onco-Hematology: an in vitro Study", coordinated by Dr. Lucia Merolle at the Department of Transfusion Medicine of the Azienda USL-IRCCS of Reggio Emilia, aims to investigate the impact of cryopreservation methods on platelet functionality and metabolism. The primary objective of this project is to determine the effects of cryogenic storage on platelet function. The study design involves the recruitment of donors, preparation of platelet concentrates, and their cryopreservation. After thawing, the products undergo a series of biochemical and functional evaluations, including platelet count, pH measurement, pro-inflammatory cytokine levels, morphological assessment, and activity testing. Data will then be analyzed to determine the minimal effective concentration required for safe and effective use. Platelet apheresis samples are collected and analyzed. Participation is proposed to platelet donors at the Department of Transfusion Medicine, and inclusion requires the signing of written informed consent, while refusal to provide consent will exclude individuals from the study.
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Platelet Recovery Rate After Cryopreservation (Percentage of Initial Count)
Timeframe: through study completion, an average of 4 year
Absolute Platelet Count After Cryopreservation (×10⁹/L)
Timeframe: through study completion, an average of 4 year
Platelet Function Assessed by Thromboelastography - Clot Formation Time
Timeframe: through study completion, an average of 4 year
Platelet Function Assessed by Thromboelastography - Maximum Amplitude
Timeframe: through study completion, an average of 4 years