A prospective multicenter randomized controlled study was conducted. Eligible very preterm infants with a gestational age of \<32 weeks were enrolled. All infants received routine treatment after birth and were randomly divided into two groups according to the FiO2 threshold of PS under noninvasive assisted ventilation: Control group (FiO2=0.30) and low concentration group (FiO2=0.25). Clinical data were collected to explore the differences in clinical outcomes between the two groups.
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Duration of tracheal intubation and mechanical ventilation
Timeframe: The children required tracheal intubation and mechanical ventilation during hospitalization, and the observation time was about 2 months
Time of first PS use
Timeframe: Time to first use of pulmonary surfactant within 6 hours after birth
Duration of noninvasive assisted ventilation
Timeframe: Noninvasive ventilation was required during hospitalization, and the observation time was about 2 months
Repeat PS usage rate
Timeframe: The frequency of repeated use of pulmonary surfactant during hospitalization was observed for about 1 week after birth
Days of Oxygen therapy
Timeframe: The children needed oxygen inhalation for a number of days during hospitalization, and the observation time was about 2 months
Failure rate of noninvasive treatment
Timeframe: 72 hours after birth