RecruitingNot Applicable

Trial of Partial Enteral Nutrition With Dairy Free Diet in Eosinophilic Esophagitis

United States36 participantsStarted 2026-03-18

Plain-language summary

This study aims to introduce a new dietary therapy for Eosinophilic Esophagitis (EoE) patients by using partial enteral nutrition (PEN) to enhance remission rates and explore how this approach affects immune function, gut microbiota, and environmental toxin exposures.

Who can participate

Age range

1 Year – 21 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Pediatric patients 1 year to 21 of age presenting with chronic symptoms of dysphagia, odynophagia, vomiting or heartburn, chronic abdominal pain, weight loss, picky eating, to outpatient gastroenterology clinic and are planning to undergo EGD for evaluation. Exclusion Criteria: * Non-English-Speaking Subjects, adults unable to consent, wards of the state, pregnant women, and prisoners will be excluded from the study. * Patients with autoimmune conditions such as inflammatory bowel disease. Patients with prior esophageal or intestinal surgeries. * Patients with history of eating disorders or ARFID. * Patients with fistulizing or fibrotic disease on baseline EGD. * Patients who have received proton pump inhibitory therapy in the past month.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Feasibility of PEN assessed by 3-day diet record

Timeframe: 3 months

Tolerability of PEN in EoE patients will be assessed by stool quality evaluated using the Bristol Stool Chart.

Timeframe: 3 months

Clinical and endoscopic remission rates assessed by mucosal eosinophilia and Eosinophilic Esophagitis Histology Scoring System (EoE-HSS) from GI tissue biopsies

Timeframe: 3 months

Immune profiles assessed by blood markers

Timeframe: 3 months

Microbiota shifts in EoE patients

Timeframe: 3 months

Environmental contaminants assessed by blood serum levels

Timeframe: 3 months

Trial details

NCT IDNCT07234825

SponsorKate Farms Inc

Sponsor typeINDUSTRY

Study typeINTERVENTIONAL

Primary completion2027-12-31

Contact for this trial

Danny Gagucas

206-987-1062 Danny.Gagucas@seattlechildrens.org

View on ClinicalTrials.gov More Eosinophilic Esophagitis (EoE) trials

Who can participate

Age range

1 Year – 21 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Feasibility of PEN assessed by 3-day diet record

Timeframe: 3 months

Tolerability of PEN in EoE patients will be assessed by stool quality evaluated using the Bristol Stool Chart.

Timeframe: 3 months

Clinical and endoscopic remission rates assessed by mucosal eosinophilia and Eosinophilic Esophagitis Histology Scoring System (EoE-HSS) from GI tissue biopsies

Timeframe: 3 months

Immune profiles assessed by blood markers

Timeframe: 3 months

Microbiota shifts in EoE patients

Timeframe: 3 months

Environmental contaminants assessed by blood serum levels

Timeframe: 3 months