Prescreening Study to Identify Potential Wilson Disease Participants for Gene-Editing Clinical Trial (NCT07226622) | Clinical Trial Compass
RecruitingNot Applicable
Prescreening Study to Identify Potential Wilson Disease Participants for Gene-Editing Clinical Trial
United States30 participantsStarted 2025-12-29
Plain-language summary
The aim of this study is to inform and improve future clinical trials in Wilson Disease (WD) by better understanding how patients with WD are living with and managing the disease, and by identifying key factors that shape their decisions to participate in clinical research.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. An established clinical diagnosis of WD
✓. Genetic analysis confirming the presence of biallelic pathogenic variants at ATP7B, at least one of which is EITHER p.H1069Q OR p.R778L OR Participants without a confirmed genetic diagnosis may enroll only with explicit approval from the Medical Monitor
Exclusion criteria
✕. Prior history of gene therapy, liver transplantation, hepatocyte (cellular) transplantation, or active listing for liver transplantation
✕. For individuals with known ATP7B genotype: individual does not have at least 1 ATP7B allele with either the p.H1069Q or p.R778L mutation.
✕. Significant neurological conditions within the prior 12 months which may impact participant safety or participation in the study, including ability to complete study requirements or procedures as outlined in the clinical study protocol.
✕. In patients with psychiatric involvement, current or fluctuant clinical instability with new or changing diagnoses or substantial medication regimen changes in the past 12 months that could limit their participation, in the opinion of the Investigator.
✕. History of cirrhotic decompensation within the past year.
✕. Any other condition that, in the opinion of the Investigator, may compromise the safety or compliance of the participant or would preclude the participant from successful study completion, including participant unable or unwilling to comply with the protocol requirements.
✕. Current participation in an investigational study for the treatment of WD.
What they're measuring
1
Gene Editing Interest & Attitudes Survey
Timeframe: From enrollment to the end of study 90 days
✕. Prior or active malignancy or myeloproliferative disorder (excluding Stage 1 or lower, fully treated/excised malignant and pre-malignant disease of the skin, cervix or colon. Additionally, any other malignant and pre-malignant disease that the Investigator in consultation with the treating oncologist and study Medical Monitor deem has been fully treated/excised for \> 5 years).