A Study on Oral and Intranasal Forms of Oxycodone in Healthy Volunteers Using Pharmacokinetic Modeling

Inclusion Criteria: * Healthy male or female volunteers according to physical examination, vital signs (blood pressure, heart rate and body temperature), ECG and safety laboratory parameters and results should be within normal ranges or considered as non-clinically relevant by the investigator. * Age ≥ 18 and ≤ 55 years. * Body weight up to 90 kg * Body mass index (BMI) ≥ 18 and ≤ 30 kg/m2. * Able/willing to be compliant with the study restrictions * Able to read Spanish and adhere to study requirements. * Signed informed consent prior to any study-mandated procedure. * Prior therapeutic or recreational experience with opioids (i.e., tramadol, oxycodone, or buprenorphine) Exclusion Criteria: * Life-time (current and/or history of) substance use disorders (SUD) according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). * Use of any illegal drug within 30 days of screening and throughout participation in the study * History of smoking or use of nicotine containing products within 3 months of screening and throughout participation in the study * No acute, chronic, or allergic rhinitis * Ongoing gastrointestinal diseases or history of gastrointestinal surgery affecting absorption. * History of severe bronchial asthma or chronic obstructive pulmonary disease, * Any anatomical abnormality or pathological condition of the nasal cavity based on medical history. * History of hypothyroidism. * Subjects with a clinically relevant disease or condition that in the …