A First-in-Human Trial of DS3790a in Participants With Hematological Malignancies

To be eligible to participate in this trial, an individual must meet all the following criteria: 1. Sign and date the ICF, prior to the start of any trial-specific procedures. 2. Adults ≥18 years at the time the ICF is signed 3. History of one of the histologically documented hematologic malignancies according to the 5th edition of WHO classification as specified in the protocol. 4. Agree to provide tumor samples as specified in the protocol. 5. ECOG PS of 0, 1 or 2 assessed no more than 14 days prior to initiation of trial intervention. 6. Has adequate organ and bone marrow function as assessed by local laboratory within 14 days prior to initiation of trial intervention as specified in the protocol. 7. Has an LVEF ≥50% by either an ECHO or MUGA within 28 days before the trial starts. 8. Life expectancy of at least 3 months. 9. Is willing and able to comply with scheduled visits, drug administration plan, laboratory tests, other trial procedures, and trial restrictions. 10. A woman of childbearing potential is eligible to participate if she meets all criteria as specified in the protocol. 11. A male participant capable of producing sperm is eligible to participate if he agrees to all criteria as specified in the protocol. An individual who meets any of the following criteria will be excluded from participating in this trial: 1. Prior Allo-SCT. 2. Prior solid organ transplantation. 3. Inadequate washout period before initiation of trial intervention as specified in the prot…