Collagenase Biobank Study

Inclusion Criteria: * English speaking. * All genders, races, and ethnicities. * Aged greater or equal to 18 years of age. * Ability to understand and the willingness to sign a written informed consent form. * Diagnosed with a colon adenocarcinoma or presumed adenocarcinoma in which surgical resection is recommended. * Have a planned surgical resection of the colon adenocarcinoma at the University of Chicago Comprehensive Cancer Center. * Reside within 150 miles of the University of Chicago Comprehensive Cancer Center. Exclusion Criteria: * Stage IV colon adenocarcinoma (known metastatic disease). * Intravenous or oral antibiotic exposure within 30 days of surgery to treat an infection. * Prebiotic exposure within 30 days of surgery. * History of neoadjuvant chemotherapy/radiation to treat the primary colon adenocarcinoma. * History of chemotherapy/radiation to treat a separate malignancy within the last 6 months. * History or current ileostomy or colostomy. * Allergy to perioperative medications (oral neomycin/metronidazole for preoperative bowel preparation, intraoperative prophylactic intravenous cefoxitin). * Patients who are pregnant. * Patients with a history of inflammatory bowel disease. * Patients with a history of bariatric surgery. * History of eating disorders.