Not Yet RecruitingPhase 2

Study of Intracerebroventricular Injections of Autologous Adipose-Derived Stem Cells (RB-ADSCs) in Participants With Mild-Moderate Alzheimer's Disease

115 participantsStarted 2025-11

Plain-language summary

The goal of this Phase 2 clinical trial is to learn if repeated dosing of RB-ADSC (an investigational autologous cell product obtained from participant's own adipose tissue) enhances the positive preliminary results seen in Phase 1 for the of treatment for mild to moderate Alzheimer's Disease in adults. The clinical trial will also continue to evaluate the safety of repeated dosing of RB-ADSC. This study will primarily evaluate the effects of repeated dosing of RB-ADSC on cognitive performance compared to placebo control. Participants will receive RB-ADSC every 2 months for a total of 6 doses. Participants randomized into the placebo control group will have the option to cross over to receive treatment after completion of the primary phase of the study.

Who can participate

Age range45 Years – 85 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * ≥45 and ≤85 years of age * Mild to moderate AD diagnosis * FAST stage 4 or 5 * MMSE 10-23 * Amyloid PET scan centiloid score \>30 * ADmark® CSF analysis of ATI (\<1.0) and P-Tau (\>60) * No tumors or other disease responsible for dementia * Participant otherwise in good general health * Written informed consent from participant or legal representative * Participant must have caregiver who separately meets specified inclusion/exclusion criteria for caregivers * Participant must be able to donate adequate amount of lipoaspirate to establish the final product Exclusion Criteria: * Taking prohibited medications * Prior cell therapy implantation * Existing ventriculoperitoneal shunts * Neurological disorders except AD * Psychiatric disorders such as schizophrenia, bipolar/unipolar depression, delirium * Drug or alcohol abuse in past 2 years * History of cancer within the past 5 years * No caregiver available to meet the inclusion criteria for caregivers * Involvement in other investigational product clinical trial within the past 3 months for monoclonal antibodies, or 6 months for other investigational products

What they're measuring

Change from Baseline on the Integrated Alzheimer's Disease Rating Scale (iADRS) Composite Score

Timeframe: Baseline, Month 6 and Month 12

Trial details

NCT IDNCT07205601

SponsorRegeneration Biomedical, Inc.

Sponsor typeINDUSTRY

Study typeINTERVENTIONAL

Primary completion2028-03

Contact for this trial

Robert Lynn

877-240-1660 robert@regenerationbiomedical.com