Circadian Health Regulation and Optimization for Rejuvenation Outcomes (NCT07203196) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Circadian Health Regulation and Optimization for Rejuvenation Outcomes
United States16 participantsStarted 2025-10-22
Plain-language summary
In this single arm intervention trial, the investigators will assess the impact of a personalized lifestyle plan, centered on supporting biological rhythms, on blood sugar levels, physical, cognitive and immune function in older adults with a habitual eating window of 12 hours or more, and elevated blood glucose levels.
All participants will be provided with a personalized circadian rhythm optimization plan (CRO) centered on improving (1) diet, (2) exercise (3) sleep habits based on their body's natural rhythms. The study includes a 2-week screening/baseline assessments, with follow-up health assessments at 2-months.
Who can participate
Age range50 Years – 80 Years
SexALL
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Inclusion criteria
✓. Age: 50-80 years
✓. Fasting glucose ≥ 100 mg/dL or HbA1c \> 5.6%
✓. Own a smartphone (Apple iOS or Android OS)
✓. Proficient in reading and speaking in English
✓. An eating window ≥12 hour/day
✓. Willing to travel to sports facilities for exercise training sessions
✓. Participants on cardiovascular medications (HMG CoA reductase inhibitors (statins), metformin, SLGT2 inhibitors, GLP1 receptor agonists other lipid-modifying drugs (including over-the counter drugs such as red yeast rice and fish oil), anti-hypertensive, drugs), are allowed if on a stable dose for 6-months, but dose adjustments are not allowed during the study
Exclusion criteria
✕. Insufficient dietary logging on the mCC app during screening, defined as less than 7 of 14 days of baseline of dietary logging with a minimum of 2 items a day, at least 5 hours apart