Study of BB-025, Alone and After BB-031, in Healthy Volunteers

Inclusion Criteria: * 18-55 years of age * Ability to provide written consent * Weight 50-100 kg with BMI 18-32 kg/m2 * Willingness to use contraceptives * Negative results for alcohol and drugs of abuse Exclusion Criteria: * Pregnant or lactating females * Familial bleeding disorder or individual or family history of bleeding diathesis or coagulopathy * Females with active menstruation on day of dosing * Use of prescription medications known to affect platelet function * Use of NSAIDs, aspirin, anti-platelet or anti-coagulation therapy within 10 days of dosing * Contraindication to anticoagulation or increased bleeding risks * History of thrombocytosis, high platelet count, intracranial bleeding, aneurysm, stroke, vascular disease * History of peptic ulcer disease, gastrointestinal or genitourinary bleed, severe trauma, fracture, major surgery of biopsy of parenchymal organ within past 3 months * Planned surgery during the study * Any clinically significant abnormality at screening * Use of investigational drug in past 30 days or 5 half lives * Concurrent enrollment in another clinical study or more than 4 clinical studies in past 12 months * Any prior history of substance abuse or treatment or positive urine screen for drugs of abuse or positive breathalyzer test