Zinc Oxide VS MEBO

Inclusion Criteria: * Willing to participate. * KAMC cases in medical ward, neuroscience ward, and intensive care unit. * Newly cases diagnosed with second stage pressure ulcer according to the European pressure ulcer advisory panel/national pressure ulcer advisory panel (NPUAP) guidelines. Exclusion Criteria: * Not consenting to participate * Patients with suspected hypersensitivity reactions to any of the topical formulation's ingredients. * Either a category III or IV pressure ulcer. * Evidence of deep tissue injury (exudative drainage, purple or maroon localized area of discolored intact skin or blood-filled blister due to pressure damage). * Signs of wound infection (pus draining from the ulcer, a foul-smelling odour, tenderness, heat and increased redness in the surrounding skin and fever). * Patients who undertaking other therapies that could affect healing, such as corticosteroids, radiation therapy, or chemotherapy for cancer. * Heavy smoking (more than 20 cigarettes a day). * Concomitant chronic disease (e.g., diabetes mellitus or frank vascular disease such as Buerger's disease). * Patients who unable to continue the study because of death, discharge, or change in the care setting.