A Study to Evaluate the Efficacy and Safety of ENX-102 in Participants With Social Anxiety Disorder (NCT07193563) | Clinical Trial Compass
CompletedPhase 2
A Study to Evaluate the Efficacy and Safety of ENX-102 in Participants With Social Anxiety Disorder
United States47 participantsStarted 2025-09-05
Plain-language summary
This is a double-blind study to evaluate the efficacy and safety of ENX-102 in participants with social anxiety disorder (SAD).
Who can participate
Age range18 Years – 70 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Key Inclusion Criteria:
* Male or female at birth, aged 18-70 years, inclusive, at screening Diagnosed with SAD according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR), confirmed by a Mini-International Neuropsychiatric Interview (MINI) version 7.0.2
* LSAS total score of ≥70
* CGI-S score of ≥4
Key Exclusion Criteria:
* Clinically predominant psychiatric diagnosis other than SAD per the MINI
* Any past/lifetime or current diagnosis of a neurocognitive disorder or psychotic disorder, or any current diagnosis of posttraumatic stress disorder, obsessive compulsive disorder, or bipolar disorder
* Reports moderately severe to severe symptoms of depression
* Frequent use of benzodiazepines within 90 days of screening
* Used prohibited medication or prohibited herbal or other supplements within 5 half- lives or 21 days prior to Day 1 and unwillingness to refrain from their use for the duration of the trial
* Recent suicidal ideation or behavior
* Current or recent moderate or severe substance use disorder as assessed by the MINI
* Is unwilling/unable to abstain from alcohol, marijuana, THC, CBD, and/or any other psychoactive substances (except for nicotine or caffeine) for the duration of the trial, per Investigator judgment, and/or has a positive alcohol test or drug test at Screening or Day 1
* Clinically significant abnormal findings in safety assessments
* Has significant progressive disorders or unstable medical condit…
What they're measuring
1
Change From Baseline on the Clinician-administered Liebowitz Social Anxiety Scale (LSAS) - Total score