Balloon Guide Catheter to Optimize Outcomes in Stroke Thrombectomy of the Internal Carotid Artery (NCT07192029) | Clinical Trial Compass
RecruitingNot Applicable
Balloon Guide Catheter to Optimize Outcomes in Stroke Thrombectomy of the Internal Carotid Artery
China364 participantsStarted 2025-10-12
Plain-language summary
To investigate whether using balloon guide catheter with flow arrest during mechanical thrombectomy, compared to non-flow arrest, improves the rate of first pass expanded Thrombolysis in Cerebral Infarction score (eTICI 2c-3) reperfusion for acute ischemic stroke due to internal carotid artery occlusion
Who can participate
Age range18 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. age ≥18 years;
✓. Clinical diagnosis of acute ischemic stroke with internal carotid artery occlusion confirmed by imaging (CTA/MRA/DSA), including isolated intracranial internal carotid artery (I-type), internal carotid artery intracranial segment involving middle cerebral artery (L-type), or internal carotid artery intracranial segment involving middle and anterior cerebral arteries (T-type) (including tandem embolic occlusions of the internal carotid artery C1 or common carotid artery);
✓. Baseline NIHSS≥6, and meeting local guidelines for mechanical thrombectomy;
✓. Time from onset or last known normal to randomization within 24 hours and proceeding to mechanical thrombectomy;
✓. Signed informed consent (or by legal representative).
Exclusion criteria
✕. Pre-stroke mRS score \>2
✕. Intracranial hemorrhage shown on imaging;
✕. Known or suspected internal carotid artery occlusion caused by dissection or atherosclerosis;
✕. Vascular tortuosity preventing the use of balloon guide catheter;
✕. Prior stent implantation in the target vessel that would impede the use or removal of mechanical thrombectomy devices;
✕. Any other circumstances impeding mechanical thrombectomy implementation;
What they're measuring
1
Rate of first-pass reperfusion defined as eTICI 2c-3 reperfusion
. Acute occlusion of multiple vascular territories in bilateral anterior circulation or in both the anterior and posterior circulations confirmed by CTA/MRA;