SSSI Efficacy With iACB and PC-LIA in TKA Pain Management (NCT07191964) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
SSSI Efficacy With iACB and PC-LIA in TKA Pain Management
90 participantsStarted 2026-06
Plain-language summary
This prospective, triple-blinded, sham-controlled randomized trial evaluates the additive effect of Supra-Sartorial Subcutaneous Infiltration (SSSI) combined with intermittent adductor canal block (iACB) and posterior capsule local infiltration analgesia (PC-LIA) for pain management in total knee arthroplasty (TKA). SSSI, a simpler alternative to targeted anterior femoral cutaneous nerve (AFCN) block, is tested in 90 adults (45-90 years) randomized into two arms: sham SSSI + active iACB + PC-LIA versus all active interventions. Primary outcome is pain scores on postoperative day 0; secondary outcomes include daily pain trajectory, opioid use, functional recovery, and complications over days 0-3.
Who can participate
Age range
45 Years – 90 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 45-90 undergoing unilateral primary TKA for osteoarthritis.
* American Society of Anesthesiologists (ASA) physical status I-III.
* Able to provide informed consent and use NRS pain scales.
* Surgery scheduled to start before noon to standardize spinal anesthesia recovery.
Exclusion Criteria:
* Bilateral or revision TKA.
* Contraindications to regional anesthesia (e.g., coagulopathy, infection at injection site).
* Chronic opioid use (\>30 mg morphine equivalents/day) or preoperative NRS \>4.
* Pre-existing neurological deficits in lower extremities or AFCN-related neuropathy.
* Allergy to ropivacaine.
* Pregnancy, breastfeeding, or cognitive impairment affecting assessments.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Pain: NRS at rest/movement on postoperative day 0 (with a focus on the anteromedial aspect of knee)