Efficacy of an AFCN Proxy Block in Post-TKA Multimodal Pain Management (NCT07191964) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Efficacy of an AFCN Proxy Block in Post-TKA Multimodal Pain Management
Taiwan90 participantsStarted 2026-08-01
Plain-language summary
This randomized controlled trial evaluates the additive effect of Supra-Sartorial Subcutaneous Infiltration (SSSI) when performed in combination with intermittent adductor canal block (iACB) and posterior capsule local infiltration analgesia (PC-LIA) for pain management after total knee arthroplasty (TKA). SSSI, an easy-to-perform tentative proxy block to targeted anterior femoral cutaneous nerve (AFCN) block, is tested in 90 adults (45-90 years) randomized into two arms: active SSSI versus sham SSSI. Primary outcome is pain scores at rest and during movement on postoperative day 0; secondary outcomes include daily pain trajectory at rest and during movement, functional recovery scores, rescue analgesic doses over days 0-3, and quality of recovery assessment on day 4.
Who can participate
Age range
45 Years – 90 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 45-90 undergoing unilateral primary TKA for osteoarthritis.
* American Society of Anesthesiologists (ASA) physical status I-III.
* Able to provide informed consent and use NRS pain scales.
* Surgery scheduled to start before noon to standardize spinal anesthesia recovery.
Exclusion Criteria:
* Bilateral or revision TKA.
* Contraindications to regional anesthesia (e.g., coagulopathy, infection at injection site).
* Chronic opioid use (\>30 mg morphine equivalents/day) or preoperative NRS \>4.
* Pre-existing neurological deficits in lower extremities or AFCN-related neuropathy.
* Allergy to ropivacaine.
* Pregnancy, breastfeeding, or cognitive impairment affecting assessments.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Pain: VAS at rest and during movement on postoperative day 0