This pilot study will test whether combining L-theanine and paraxanthine improves sustained attention, inhibitory control, and overall cognition in adults with ADHD and ASD. Two parallel randomized, single-blinded, repeated-measures crossover trials will be conducted. Participants will complete neuropsychological testing, fMRI scanning, and self-report measures following administration of the L-theanine-paraxanthine combination compared to placebo.
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fMRI task-related activity
Timeframe: At visit 2 or 3, 30 minutes after intake of L-theanine-paraxanthine or placebo.
Stop Signal Reaction Time
Timeframe: At visit 2 or 3, 30 minutes after intake of L-theanine-paraxanthine or placebo. This task is performed while in the MRI.
d-prime (sensitivity to the Go signal)
Timeframe: At visit 2 or 3, 30 minutes after intake of L-theanine-paraxanthine or placebo. This task is performed while in the MRI.
Chathurika S Dhanasekara, MD, PhD