Not Yet RecruitingPhase 1

Locoregional or Systemic Administration of Autologous Tumor Infiltrating Lymphocytes in Patients With Metastatic Melanoma

18 participantsStarted 2026-03

Plain-language summary

The purpose of this study is to evaluate the feasibility, safety and tolerability of locoregional or systemic administration of autologous tumor infiltrating lymphocytes in patients with metastatic melanoma

Who can participate

Age range18 Years – 90 Years

SexALL

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Inclusion criteria

✓. Participants must be at least 18 years of age.
✓. Can provide a signed informed consent as described in the protocol, including compliance with the requirements and restrictions listed in the ICF and in this protocol.
✓. World Health Organization (WHO) Performance Status 0 or 1.
✓. Patient must have a histologically/cytologically confirmed diagnosis of:
✓. At least one resectable lesion in the liver (or aggregate of lesions resected) of a minimum size of 0.5 cm in diameter to generate TILs.
✓. Measurable disease by computed tomography (CT) per RECIST 1.1 criteria after resection of lesion for TILs production
✓. No other malignancies, except if treated with curative intent and with a cancer-related life expectancy of more than 5 years.
✓. Female patient of childbearing potential should have a negative urine or serum pregnancy test within 72 hours prior to receiving the first treatment. If the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required.

Exclusion criteria

✕. Any serious or uncontrolled medical conditions that, in the investigator's opinion, may increase the risk associated with study participation or study drug administration, impair the ability of the subject to receive protocol therapy (including operation), or interfere with the interpretation of study results.
✕. Subjects with a condition requiring systemic treatment with either corticosteroids (\> 10 mg daily prednisone equivalents) or other immunosuppressive medications within 14 days of study drug administration. Inhaled or topical steroids and adrenal replacement doses \> 10 mg daily prednisone equivalents are permitted in the absence of active autoimmune disease.
✕. Women who are pregnant or breastfeeding.
✕. Any condition that potentially hamper compliance with the study protocol and follow-up schedule; those conditions should be discussed with the subject before registration in the trial.

What they're measuring

Incidence and severity of adverse events

Timeframe: 5 years

Trial details

NCT IDNCT07183852

SponsorVastra Gotaland Region

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2028-03

Contact for this trial

Lars Ny, PhD

+46 31 342 40 11 lars.ny@vgregion.se

View on ClinicalTrials.gov More Metastatic Uveal Melanoma trials