The goal of this study is to test a new pacing method called anodal biphasic pacing (ABP) to determine if this pacing works as well-or better-than current pacing methods. This new method may improve how the heart works and reduce some of the problems caused by regular pacing. Current implantable pacemakers use a monophasic cathodal waveform to stimulate the heart. Monophasic cathodal pacing (MCP) waveforms slow conduction, impair contractility, cause inflammation, increase risk of atrial fibrillation, heart failure, and mortality. Anodal biphasic pacing (ABP) is an alternative waveform that can stimulate the heart. ABP preconditions the heart and then initiates cardiac contraction. ABP may address the limitations of MCP.
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Clinically significant maximum rate of pressure change maximum rate of pressure change within the left ventricle during its contraction phase- dP/dtmax.
Timeframe: about 30 minutes
Clinically significant stroke work
Timeframe: about 30 minutes
Clinically significant left ventricular end-diastolic pressure (LVEDP)
Timeframe: about 30 minutes
Clinically significant diastolic relaxation (tau)
Timeframe: about 30 minutes
Clinically significant volume measurements
Timeframe: about 30 minutes
Capture threshold
Timeframe: about 30 minutes