A Phase Ib/II Study of QLC1401 Combined With CDK4/6 or mTOR Inhibitors in ER+/HER2- Advanced Breast Cancer

Inclusion Criteria: * Voluntarily participate in the clinical trial, understand and sign the informed consent form, and agree to comply with the requirements specified in the protocol. * Age ≥ 18 years. * Female subjects must be postmenopausal and meet the trial requirements. * Eastern Cooperative Oncology Group (ECOG) performance status score of 0 to 1. * Life expectancy ≥ 3 months. * Histologically or cytologically confirmed breast cancer. * Based on the most recent biopsy results of primary or metastatic tumor tissue, immunohistochemistry (IHC) confirms ER-positive status and HER-2-negative status. * At least one measurable target lesion according to RECIST v1.1. * Adequate bone marrow function within 2 weeks (14 days) prior to the initiation of study treatment, without the need for transfusion or growth factor (G-CSF, EPO, TPO, etc.) support. * Adequate liver function. * Renal function: serum creatinine ≤ 1.5 × upper limit of normal (ULN) or creatinine clearance (Ccr) \> 30 mL/min, with no significant electrolyte imbalances that are difficult to correct. * Coagulation function: International Normalized Ratio (INR) or prothrombin time (PT) and activated partial thromboplastin time (APTT) ≤ 1.5 × ULN. Exclusion Criteria: * Presence of symptomatic visceral disease or any other condition deemed unsuitable for endocrine therapy as per the investigator's judgment. * Presence of unresolved toxicities from prior therapy that have not recovered to ≤ CTCAE grade 1, excluding alo…