A Rollover Study Evaluating Sotorasib With or Without Panitumumab in Participants With KRAS p.G12… (NCT07172919) | Clinical Trial Compass
RecruitingPhase 2
A Rollover Study Evaluating Sotorasib With or Without Panitumumab in Participants With KRAS p.G12C Mutation
United States, Australia, France14 participantsStarted 2026-01-02
Plain-language summary
The primary objective of the study is to evaluate the safety and tolerability of the continuation of sotorasib with or without panitumumab and/or other anti-cancer therapies in participants continuing to derive benefit in Amgen-sponsored protocols.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
* Signed informed consent.
* Age ≥ 18 years.
* Life expectancy of \> 3 months, in the opinion of the investigator.
* Ability to take oral medications and willing to record daily adherence to sotorasib through the use of a written diary.
* Participant is currently receiving treatment with sotorasib alone or in combination therapy in an Amgen-sponsored trial that has met its endpoints or otherwise will be stopping (also referred to as parent study) and are continuing to receive clinical benefit in the opinion of the investigator.
* For a participant on combination therapy in their parent study, treatment with other anti-cancer therapies is allowed provided it matches the parent study.
* Eastern Cooperative Oncology Group Performance Status of ≤ 2.
Exclusion Criteria:
* Participant had permanently discontinued from sotorasib study treatment in the parent study before the parent study's completion.
* Ongoing, unresolved toxicity requiring interruption of sotorasib treatment at the time of the termination of the parent study.
* Local access to commercially available investigational product(s) at no cost to the participant as permitted by local/country regulation.
* Anticipated toxicities of sotorasib study treatment outweigh the clinical benefit to the participant in the opinion of the investigator.
* Participant unlikely to be able to complete all protocol-required procedures, restrictions and requirements, in the judgment of the individual and investigator…
What they're measuring
1
Number of Participants with Treatment-Emergent Adverse Events (TEAEs)