RecruitingNot Applicable

Modulate Tremor Severity With Low-intensity Focused Ultrasound Stimulation Targeting the Deep Nucleus of Patients With Refractory Hand Tremor.

Taiwan12 participantsStarted 2025-06-11

Plain-language summary

The study plans to recruit 12 patients with Parkinsonian tremor, essential tremor, or dystonic tremor. After receiving NaviFUS-ctbTUS stimulation, the improvement in their tremor will be recorded.

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion criteria

✓. Patients with Parkinson's disease tremor who have an inadequate response to medication.
✓. Patients with essential tremor who have an inadequate response to medication.
✓. Patients with dystonic tremor who have an inadequate response to medication.

Exclusion criteria

✕. Platelet count ≤ 100,000/µL
✕. INR ≥ 1.5
✕. PT ≥ 1.5 × upper limit of normal (ULN)
✕. aPTT ≥ 1.5 × ULN
✕. Fibrinogen ≤ 150 mg/dL

What they're measuring

Incidence of Adverse Events Compared to Baseline [Safety Assessment]

Timeframe: Day of first stimulation, 7 days after first stimulation, day of second stimulation, 7 days after second stimulation, and 28 days after second stimulation.

Trial details

NCT IDNCT07172295

SponsorNational Taiwan University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-06-30

Contact for this trial

Kai-Hsiang Kai-Hsiang, M.D.

+886-3-5326151 stanleychen1230@gmail.com

View on ClinicalTrials.gov More Parkinson Disease (PD) trials