Combined Whey Protein and Collagen Supplementation in Resistance-Trained Men (NCT07171411) | Clinical Trial Compass
CompletedNot Applicable
Combined Whey Protein and Collagen Supplementation in Resistance-Trained Men
Turkey (Türkiye)40 participantsStarted 2024-01-03
Plain-language summary
This study tested whether taking whey protein together with collagen peptides would provide greater benefits for muscle and bone health compared to whey protein alone, collagen alone, or a placebo. Forty healthy, resistance-trained men aged 18-35 years were randomly assigned to one of four groups: (1) whey protein plus collagen (30 g + 10 g/day), (2) whey protein only (30 g/day), (3) collagen only (10 g/day), or (4) placebo (maltodextrin). All participants followed a supervised resistance training program (3 times per week) for 8 weeks.
The primary outcome was muscle mass, measured with bioelectrical impedance analysis (BIA). Secondary outcomes included bone mineral density (DXA scans), maximal strength (1RM squat and bench press), and blood markers of bone turnover (P1NP and CTX-I).
Results showed that the whey + collagen group achieved the largest improvements in muscle growth, lumbar spine bone mineral density, strength, and favorable changes in bone turnover markers compared to all other groups. No serious side effects were reported, and supplement adherence was very high.
These findings suggest that combining whey protein and collagen may be a practical strategy to support muscle and bone adaptation in resistance-trained men.
Who can participate
Age range
18 Years – 35 Years
Sex
MALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Male participants aged 18-35 years
* At least 1 year of consistent resistance training experience (≥3 sessions per week, targeting major muscle groups)
* Healthy, with no history of musculoskeletal, metabolic, or cardiovascular disorders
* No current or recent (\<6 months) use of anabolic steroids, growth hormones, or performance-enhancing substances
* Non-smoker and no habitual use of anti-inflammatory medications
* Able and willing to comply with supplementation and supervised training program
* Provided written informed consent
Exclusion Criteria:
* Participation in similar supplementation studies in the past 6 months
* Recent fractures or surgeries affecting musculoskeletal health (\<6 months)
* Known allergy or intolerance to dairy proteins or collagen supplements
* Inability to attend scheduled supervised resistance training sessions
* Non-adherence to dietary control requirements (e.g., use of additional protein/creatine supplements during study)
* Any condition deemed by investigators to interfere with study compliance or safety
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Muscle Mass (kg, lean body mass by BIA)
Timeframe: Baseline (week 0) to 8 weeks post-intervention