The Role of the LC-NA System in Experimental Sleep Fragmentation

Inclusion Criteria: * Age between 18 - 35 years (inclusive) * Body-Mass-Index (BMI): 18.5 \< BMI \< 25 * Non-nicotine user status * Habitual consumption of 5 or fewer alcoholic beverages / week * Habitual consumption of 3 or fewer caffeinated beverages / day * Habitual average sleep duration 7-9 h / night * Normal or corrected-to-normal vision * Insomnia severity Index (ISI) Score: ISI \< 8 * Ability to understand and speak German language * Normal hearing ability (applies only to Sleep Study Part) * Ability and willingness to provide informed consent as documented by dated signature Exclusion Criteria: * Present use of medication that may interfere with sleep or study drugs * Travel across 3 or more time zones within 3 months of study start * Habitual napping * Extreme chronotype, determined by reduced Morningness-Eveningness Questionnaire (rMEQ) score: 8 \< rMEQ \> 21) * Shift working within 2 weeks prior to the screening visit * History of or presence of a trauma- or stressor-related disorder * Serious acute or chronic neurological, mental, or general medical conditions that, in the opinion of the investigator, may pose a risk to participation or affect study measurements * History of or presence of a sleep wake disorder * Use of illicit drugs (positive urinary drug screening) * Male participants who are not vasectomised for at least 6 months prior to dosing and who are sexually active with a female partner of childbearing potential not willing to use one of the followi…