Parent Study Name: Pulmonary Rehabilitation to Reduce Post-Tuberculosis Morbidity (TB Pure) (NCT07164742) | Clinical Trial Compass
RecruitingNot Applicable
Parent Study Name: Pulmonary Rehabilitation to Reduce Post-Tuberculosis Morbidity (TB Pure)
India690 participantsStarted 2026-03-18
Plain-language summary
Individual-level, unblinded randomized controlled trial of an 8-week (short arm) or 24-week (extended arm) pulmonary rehabilitation program, relative to standard of care, to prevent post-tuberculosis respiratory morbidity. Randomization will occur in a 1:1:1 ratio at the initiation of treatment.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
* Age at least 18 years
* Microbiologically confirmed (smear microscopy, GeneXpert or culture) pulmonary TB disease\*
* Not completed more than 2 weeks of TB treatment
* Receiving TB care at the outpatient clinics at the TB PuRe study sites
* Willingness to complete 48 weeks of study evaluations.
* Access to a smartphone.
Exclusion Criteria:
* Modified Medical Research Council score of 0 points (dyspnea only with strenuous exercise)
* Multi or extensively drug-resistant TB disease\*
* Extrapulmonary TB disease at any clinical sites without pulmonary involvement
* TB meningitis or TB of the spine
* Symptomatic cardiovascular disease, including coronary artery disease, arrhythmias and congestive cardiac failure.
* Karnofsky Score \< 40 points
* Any medical condition that prevents pulmonary rehabilitation eg: fracture of lower/upper limbs/pregnancy
* Bronchodilators and/or corticosteroids inhaled or otherwise.